Is (+-)-Isradipine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use (+-)-Isradipine? Is (+-)-Isradipine safe for nursing mother and child? Does (+-)-Isradipine extracts into breast milk? Does (+-)-Isradipine has any long term or short term side effects on infants? Can (+-)-Isradipine influence milk supply or can (+-)-Isradipine decrease milk supply in lactating mothers?
(+-)-Isradipine lactation summary
- DrLact safety Score for (+-)-Isradipine is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of (+-)-Isradipine may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that (+-)-Isradipine may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of (+-)-Isradipine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using (+-)-Isradipine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About (+-)-Isradipine usage in lactation
At latest update no published data were found on excretion into breast milk. Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.Its high plasma protein binding capacity makes it highly unlikely a passage into milk.Although it has a low oral bioavailability this may increase by 20% when administered with a meal, which would increase the oral absorption in the infant. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Answer by DrLact: About (+-)-Isradipine usage in lactation
Because no information is available on the use of (+-)-Isradipine during breastfeeding, an alternate drug may be preferred.
Alternate Drugs
Amlodipine(Low Risk)
Felodipine(Low Risk)
Carvedilol(Low Risk)
Methyldopa(Safe)
Bisoprolol(Low Risk)
Nebivolol(Unsafe)
Enalapril(Safe)
Lisinopril(Low Risk)
Nitrendipine(Safe)
Atenolol(Unsafe)
Nicardipine(Safe)
Valsartan(Low Risk)
Acebutolol(Unsafe)
Timolol(Safe)
Terazosin(Unsafe)
Diltiazem(Safe)
Isradipine(Low Risk)
Sotalol(Low Risk)
Nisoldipine(Low Risk)
Telmisartan(Unsafe)
Propranolol(Safe)
Prazosin(Unsafe)
Chlorthalidone(Dangerous)
Verapamil(Safe)
Indapamide(Low Risk)
Chlorothiazide(Safe)
Nimodipine(Safe)
Losartan(Low Risk)
Captopril(Safe)
Trandolapril(Dangerous)
Hydrochlorothiazide(Safe)
Nadolol(Unsafe)
Irbesartan(Unsafe)
Bumetanide(Low Risk)
Torsemide(Low Risk)
Metoprolol(Safe)
Spironolactone(Safe)
Hydralazine(Safe)
Nifedipine(Safe)
Bendroflumethiazide(Unsafe)
Reserpine(Unsafe)
Furosemide(Low Risk)
Doxazosin(Safe)
Eprosartan(Low Risk)
Benazepril(Safe)
Ramipril(Low Risk)
Fosinopril(Low Risk)
Levobunolol(Low Risk)
Bosentan(Low Risk)
Labetalol(Safe)
Minoxidil(Safe)
Guanfacine(Low Risk)
Nitrendipine(Safe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Nifedipine(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Nitroglycerin(Safe)
Nitrendipine(Safe)
Nebivolol(Unsafe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Nifedipine(Safe)
Hydralazine(Safe)
Minoxidil(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Sildenafil(Safe)