Is MP-376 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use MP-376? Is MP-376 safe for nursing mother and child? Does MP-376 extracts into breast milk? Does MP-376 has any long term or short term side effects on infants? Can MP-376 influence milk supply or can MP-376 decrease milk supply in lactating mothers?

Is the S-isomer of ofloxacin. Recently, quinolone-related medication has been used in neonates and infants without apparent side effects. It trespasses in tiny amounts into breast milk. Absorption through the child’s gut may be interfered by the calcium contained in the milk. Should it be necessary to prescribe it to a nursing mother, Norfloxacine, Ofloxacine and Ciprofloxacine have shown a lower level in the milk and thus must be the preferred drugs. Because a case of pseudomembranose colitis has been described possibly related to mother ingestion of Ciporfloxacine in a premature infant previously affected of NEC, a close follow-up for diarrhea is warranted. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

MP-376 is the -enantiomer of the fluoroquinolone, ofloxacin. No information is available on the clinical use of MP-376 during breastfeeding. However, amounts in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. Fluoroquinolones such as MP-376 have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, recent studies indicate little risk.[1][2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. Use of MP-376 is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). Avoiding breastfeeding for 4 to 6 hours after a dose should decrease the exposure of the infant to MP-376 in breastmilk. Maternal use of an eye drop that contains MP-376 presents negligible risk for the nursing infant.