I am a breastfeeding mother and i want to know if it is safe to use SAM-e? Is SAM-e safe for nursing mother and child? Does SAM-e extracts into breast milk? Does SAM-e has any long term or short term side effects on infants? Can SAM-e influence milk supply or can SAM-e decrease milk supply in lactating mothers?

SAM-e lactation summary

SAM-e is safe in breastfeeding
  • DrLact safety Score for SAM-e is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of SAM-e is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that SAM-e does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of SAM-e safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About SAM-e usage in lactation

A molecule that is synthesized by joining Methionine to ATP which is naturally widely present in human body. Without any clear scientific base it is used for liver disorders, depression and osteoarthritis. It is a product with low therapeutic effectiveness.

Answer by DrLact: About SAM-e usage in lactation

SAM-e (S-adenosylmethionine) is a naturally occurring methyl radical donor involved in enzymatic transmethylation reactions in humans and animals. SAM-e has no specific lactation-related uses, but it has been used therapeutically for treating postpartum depression, cholestatic jaundice, osteoarthritis and numerous other conditions. SAM-e has poor oral bioavailability. SAM-e is generally well tolerated in adults. The most frequent adverse effects reported are gastrointestinal, such as nausea. Skin rashes have also been reported. No information is available on the clinical use of SAM-e during breastfeeding. However, use of SAM-e by a nursing mother would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.[1][2] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.