Is N-(2,3-Xylyl)-2-aminobenzoic acid Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use N-(2,3-Xylyl)-2-aminobenzoic acid? Is N-(2,3-Xylyl)-2-aminobenzoic acid safe for nursing mother and child? Does N-(2,3-Xylyl)-2-aminobenzoic acid extracts into breast milk? Does N-(2,3-Xylyl)-2-aminobenzoic acid has any long term or short term side effects on infants? Can N-(2,3-Xylyl)-2-aminobenzoic acid influence milk supply or can N-(2,3-Xylyl)-2-aminobenzoic acid decrease milk supply in lactating mothers?

N-(2,3-Xylyl)-2-aminobenzoic acid lactation summary

N-(2,3-Xylyl)-2-aminobenzoic acid is safe in breastfeeding

DrLact safety Score for N-(2,3-Xylyl)-2-aminobenzoic acid is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of N-(2,3-Xylyl)-2-aminobenzoic acid is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that N-(2,3-Xylyl)-2-aminobenzoic acid does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of N-(2,3-Xylyl)-2-aminobenzoic acid safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About N-(2,3-Xylyl)-2-aminobenzoic acid usage in lactation

Excretion into breast milk is non-significant without side-effects reported in breastfed infants from treated mothers. It was not found, or, only in very low levels neither in the plasma nor the urine of those infants. Because of a paucity of published reports on it, it is recommended the use of alternative medication in the neonatal period or in case of prematurity. The American Academy of Pediatrics (2012) rates it as a maternal medication that is usually compatible with breastfeeding.

Answer by DrLact: About N-(2,3-Xylyl)-2-aminobenzoic acid usage in lactation

If N-(2,3-Xylyl)-2-aminobenzoic acid is required by the mother, it is not a reason to discontinue breastfeeding. Because there is little published experience with N-(2,3-Xylyl)-2-aminobenzoic acid during breastfeeding and it is potentially toxic, other agents may be preferred, especially while nursing a newborn or preterm infant.

N-(2,3-Xylyl)-2-aminobenzoic acid Side Effects in Breastfeeding

Ten newborns were breastfed for 4 days during maternal intake of N-(2,3-Xylyl)-2-aminobenzoic acid. No mention was made of infant side effects or lack thereof.[1]