Question

I am a breastfeeding mother and i want to know if it is safe to use BRN 6940582? Is BRN 6940582 safe for nursing mother and child? Does BRN 6940582 extracts into breast milk? Does BRN 6940582 has any long term or short term side effects on infants? Can BRN 6940582 influence milk supply or can BRN 6940582 decrease milk supply in lactating mothers?

BRN 6940582 lactation summary

BRN 6940582 is safe in breastfeeding
  • DrLact safety Score for BRN 6940582 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of BRN 6940582 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that BRN 6940582 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of BRN 6940582 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About BRN 6940582 usage in lactation

Antibacterial carbapenem beta-lactam with indications similar to imipenem.Intravenous administration every 8 hours. It is excreted in breast milk in a clinically insignificant amount (Sauberan 2012) and no problems have been observed in infants whose mothers took it (Festini 2004). Authorized pediatric use in infants and newborns. It is considered by experts to be compatible with breastfeeding (Rowe 2013). The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to altered intestinal flora (Benyamini 2005, Ito 1993, Kafetzis 1981).

Answer by DrLact: About BRN 6940582 usage in lactation

Although no information is available on the use of BRN 6940582 during breastfeeding, milk levels appear to be low and beta-lactams are generally not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with beta-lactams, but these effects have not been adequately evaluated. Vaborbactam, which is available in the combination product Vabomere, has not been studied in nursing mothers, but the combination is expected to have similar concerns as with BRN 6940582 alone.

BRN 6940582 Side Effects in Breastfeeding

A mother received BRN 6940582 1 gram IV every 8 hours for 7 days while exclusively breastfeeding her newborn. When questioned later, she stated that her infant had no oral thrush, watery diarrhea, or diaper dermatitis that required antifungal therapy during the month following her BRN 6940582 therapy.[1] An infant was breastfed (extent not stated) until the 4th month postpartum. At 2 months of age, his mother was given a 2-week course of tobramycin and BRN 6940582 (dosage not specified) for a cystic fibrosis exacerbation. The infant displayed no change in stool pattern during the maternal treatment and had normal renal function at 6 months of age.[2]

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