Is Disopyramide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Disopyramide? Is Disopyramide safe for nursing mother and child? Does Disopyramide extracts into breast milk? Does Disopyramide has any long term or short term side effects on infants? Can Disopyramide influence milk supply or can Disopyramide decrease milk supply in lactating mothers?
Disopyramide lactation summary
- DrLact safety Score for Disopyramide is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Disopyramide is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Disopyramide does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Disopyramide safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Disopyramide usage in lactation
American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.
Answer by DrLact: About Disopyramide usage in lactation
Disopyramide is sometimes found in the plasma of nursing infants at levels of 7.5-12.5% of the mother's levels. The N-monodesalkyldisopyramide (NMD) metabolite is more anticholinergic than disopyramide itself and appears in breastmilk in levels higher than disopyramide. However, of the cases reported, there are no reports of infant effects. Disopyramide may be used cautiously while breastfeeding when other alternatives are unacceptable. Observe the infant for anticholinergic symptoms. Infant serum concentrations can be monitored if there is any concern about drug-induced adverse effects. Theoretically, disopyramide might decrease the milk supply.
Disopyramide Side Effects in Breastfeeding
There are reports of 2 infants who were breastfed without complications during maternal disopyramide use of 500 to 600 mg daily.[1][2] Infant symptoms of crying and restlessness after meals thought by one mother to be caused by disopyramide in breastmilk were judged to be unrelated by the examining physicians.[3]
Alternate Drugs
Atenolol(Unsafe)
Acebutolol(Unsafe)
Verapamil(Safe)
Quinidine(Safe)
Lidocaine(Safe)
Propafenone(Low Risk)
Timolol(Safe)
Procainamide(Safe)
Sotalol(Low Risk)
Mexiletine(Safe)
Propranolol(Safe)
Flecainide(Safe)
Disopyramide(Safe)
Nadolol(Unsafe)
Diltiazem(Safe)
Metoprolol(Safe)
Digoxin(Safe)
Levobunolol(Low Risk)
Amiodarone(Unsafe)
Labetalol(Safe)
Bisoprolol(Low Risk)