Is Minocyclinum Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Minocyclinum? Is Minocyclinum safe for nursing mother and child? Does Minocyclinum extracts into breast milk? Does Minocyclinum has any long term or short term side effects on infants? Can Minocyclinum influence milk supply or can Minocyclinum decrease milk supply in lactating mothers?

Many reviews state that tetracyclines are contraindicated during breastfeeding because of possible staining of infants' dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is not likely to be harm in short-term use of Minocyclinum during lactation because milk levels are low and absorption by the infant is inhibited by the calcium in breastmilk. Short-term use of Minocyclinum is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). Black discoloration of breastmilk has been reported with Minocyclinum.

A woman taking Minocyclinum 100 mg twice daily for almost 4 years developed galactorrhea after taking perphenazine, amitriptyline and diphenhydramine, and the breast secretion was black in color.[2]Another woman who had nursed her infant and produced occasional small amounts of breastmilk during the 18 months after weaning was given oral Minocyclinum 150 mg daily. After 3 to 4 weeks, expressed milk had become black. Iron levels in milk were over 100 times greater than that found in normal milk. A mammogram was normal.[3]In both of these cases, macrophages containing a black, iron-containing pigment were found in milk. It is thought that the pigment is an iron chelate of Minocyclinum or one of its metabolites.[2][3]