Is U-10,858 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use U-10,858? Is U-10,858 safe for nursing mother and child? Does U-10,858 extracts into breast milk? Does U-10,858 has any long term or short term side effects on infants? Can U-10,858 influence milk supply or can U-10,858 decrease milk supply in lactating mothers?
U-10,858 lactation summary
- DrLact safety Score for U-10,858 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of U-10,858 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that U-10,858 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of U-10,858 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About U-10,858 usage in lactation
It is excreted into breast milk in non-significant amount without side-effects observed among infants whose mothers were taking this medication. This small risk can further be minimized by avoiding to nurse one hour after taking the medication, a time at which milk level is higher (4, 10, 20 and 40 times higher than if occurs within 3, 6, 9 and 12 hours respectively) The American Academy of Pediatrics states that it is usually compatible with breastfeeding. Because, few published experience is available, it would be preferred better known options, especially within the neonatal period or in case of prematurity.
Answer by DrLact: About U-10,858 usage in lactation
Because of the minimal amount of information on this potent agent, use U-10,858 with caution, particularly when therapy involves a large maternal dosage or breastfeeding a newborn. Topical U-10,858 should pose low risk to the breastfed infant.
U-10,858 Side Effects in Breastfeeding
No hypertrichosis or other abnormal signs were seen in one infant breastfed for 2 months of maternal U-10,858 therapy.[1]
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