Is 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine? Is 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine safe for nursing mother and child? Does 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine extracts into breast milk? Does 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine has any long term or short term side effects on infants? Can 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine influence milk supply or can 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine decrease milk supply in lactating mothers?
2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine lactation summary
- DrLact safety Score for 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine usage in lactation
It is excreted into breast milk in non-significant amount without side-effects observed among infants whose mothers were taking this medication. This small risk can further be minimized by avoiding to nurse one hour after taking the medication, a time at which milk level is higher (4, 10, 20 and 40 times higher than if occurs within 3, 6, 9 and 12 hours respectively) The American Academy of Pediatrics states that it is usually compatible with breastfeeding. Because, few published experience is available, it would be preferred better known options, especially within the neonatal period or in case of prematurity.
Answer by DrLact: About 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine usage in lactation
Because of the minimal amount of information on this potent agent, use 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine with caution, particularly when therapy involves a large maternal dosage or breastfeeding a newborn. Topical 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine should pose low risk to the breastfed infant.
2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Side Effects in Breastfeeding
No hypertrichosis or other abnormal signs were seen in one infant breastfed for 2 months of maternal 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine therapy.[1]
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