Is 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide? Is 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide safe for nursing mother and child? Does 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide extracts into breast milk? Does 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide has any long term or short term side effects on infants? Can 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide influence milk supply or can 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide decrease milk supply in lactating mothers?

It is excreted into breast milk in non-significant amount without side-effects observed among infants whose mothers were taking this medication. This small risk can further be minimized by avoiding to nurse one hour after taking the medication, a time at which milk level is higher (4, 10, 20 and 40 times higher than if occurs within 3, 6, 9 and 12 hours respectively) The American Academy of Pediatrics states that it is usually compatible with breastfeeding. Because, few published experience is available, it would be preferred better known options, especially within the neonatal period or in case of prematurity.

Because of the minimal amount of information on this potent agent, use 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide with caution, particularly when therapy involves a large maternal dosage or breastfeeding a newborn. Topical 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide should pose low risk to the breastfed infant.

No hypertrichosis or other abnormal signs were seen in one infant breastfed for 2 months of maternal 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide therapy.[1]