I am a breastfeeding mother and i want to know if it is safe to use Taliglucerase alfa? Is Taliglucerase alfa safe for nursing mother and child? Does Taliglucerase alfa extracts into breast milk? Does Taliglucerase alfa has any long term or short term side effects on infants? Can Taliglucerase alfa influence milk supply or can Taliglucerase alfa decrease milk supply in lactating mothers?
No information is available on the clinical use of taliglucerase alfa during breastfeeding. Taliglucerase alfa is a biosynthetic synthetic enzyme closely related to beta-glucocerebrosidase, which is a normal component of human milk. Because it is a large protein molecule with a molecular weight of about 61,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract.[1][2] A limited amount of data support the safety of breastfeeding with alglucerase (the placenta-derived form of the enzyme) and imiglucerase (another biosynthetic form of the enzyme). An international panel of clinicians from 9 centers that treat Gaucher's disease reported that, breastfeeding complications were less frequent in mothers who were treated with alglucerase or imiglucerase postpartum than in untreated mothers with Gaucher's disease. Consider limiting the duration of breastfeeding to about 6 months to avoid excessive bone loss in the nursing mother.[2][3]
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