Is CCRIS 7604 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use CCRIS 7604? Is CCRIS 7604 safe for nursing mother and child? Does CCRIS 7604 extracts into breast milk? Does CCRIS 7604 has any long term or short term side effects on infants? Can CCRIS 7604 influence milk supply or can CCRIS 7604 decrease milk supply in lactating mothers?

Drug is cleared from the body in 3-5 elimination half-lives. Resuming breastfeeding is likely safe after 2 - 3 months of of pumping-and-dumping.

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, such as CCRIS 7604.[1][2] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one patient, CCRIS 7604 was still detectable in milk 28 days after a dose of 6 mg per square meter. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[4]

One mother received 3 daily doses of 6 mg/sq m of CCRIS 7604 intravenously along with 5 daily doses of etoposide 80 mg/sq m and cytarabine 170 mg/sq m intravenously. She resumed breastfeeding her infant 3 weeks after the third dose of CCRIS 7604 at a time when CCRIS 7604 was still detectable in milk. The infant had no apparent abnormalities at 16 months of age.[3]