Question

I am a breastfeeding mother and i want to know if it is safe to use 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon? Is 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon safe for nursing mother and child? Does 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon extracts into breast milk? Does 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon has any long term or short term side effects on infants? Can 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon influence milk supply or can 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon decrease milk supply in lactating mothers?

1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon lactation summary

1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon is dangerous in breastfeeding
  • DrLact safety Score for 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon is 7 out of 8 which is considered Dangerous as per our analyses.
  • A safety Score of 7 indicates that usage of 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon may cause toxic or severe side effects in breastfed baby.
  • Our study of different scientific research indicates that 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon .
  • Usage of 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon is in contradiction to breastfeeding hence if it is must to use 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon usage in lactation

Drug is cleared from the body in 3-5 elimination half-lives. Resuming breastfeeding is likely safe after 2 - 3 months of of pumping-and-dumping.

Answer by DrLact: About 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon usage in lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, such as 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon.[1][2] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one patient, 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon was still detectable in milk 28 days after a dose of 6 mg per square meter. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[4]

1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon Side Effects in Breastfeeding

One mother received 3 daily doses of 6 mg/sq m of 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon intravenously along with 5 daily doses of etoposide 80 mg/sq m and cytarabine 170 mg/sq m intravenously. She resumed breastfeeding her infant 3 weeks after the third dose of 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon at a time when 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon was still detectable in milk. The infant had no apparent abnormalities at 16 months of age.[3]

Alternate Drugs

Carboplatin(Dangerous)
Paclitaxel(Dangerous)
Hydroxyurea(Low Risk)
Fluorouracil(Dangerous)
Etoposide(Dangerous)
Nivolumab(Unsafe)
Doxorubicin(Dangerous)
Gemcitabine(Dangerous)
Alemtuzumab(Low Risk)
Vinblastine(Dangerous)
Cyclophosphamide(Dangerous)
Rituximab(Low Risk)
Bleomycin(Dangerous)
Docetaxel(Dangerous)
Cisplatin(Unsafe)
Bevacizumab(Low Risk)
Pazopanib(Unsafe)
Vinorelbine(Dangerous)
Busulfan(Dangerous)
Dacarbazine(Dangerous)
Trastuzumab(Unsafe)
Imatinib(Unsafe)
Thioguanine(Dangerous)
Cladribine(Dangerous)
Erlotinib(Unsafe)
Letrozole(Dangerous)
Dasatinib(Unsafe)
Exemestane(Dangerous)
Vincristine(Dangerous)
Nilotinib(Unsafe)
Tamoxifen(Dangerous)
Ipilimumab(Unsafe)
Mitoxantrone(Dangerous)
Dactinomycin(Dangerous)
Cetuximab(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.