Is Sibutramine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Sibutramine? Is Sibutramine safe for nursing mother and child? Does Sibutramine extracts into breast milk? Does Sibutramine has any long term or short term side effects on infants? Can Sibutramine influence milk supply or can Sibutramine decrease milk supply in lactating mothers?

• DrLact safety Score for Sibutramine is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Sibutramine may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Sibutramine may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Sibutramine .
• It is recommended to evaluate the advantage of not breastfeeding while using Sibutramine Vs not using Sibutramine And continue breastfeeding.
• While using Sibutramine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

On latest update relevant published data on breastfeeding were not found. Because of high protein-binding, excretion into breast milk seems unlikely. Medication used as anorexigen. Amphetamine-like drug that acts as reuptake inhibitor of Serotonin, Norepinephrine and Dopamine. May cause increase of Prolactin and Galactorrhea. Because of cardiovascular side effects (Arrhythmia, Hypertension, Heart infarction) several regulatory agencies (EMEA, FDA) have withdrawn it from the market in many countries. Breastfeeding mothers return to their pre- pregnancy body weight sooner than others who don't.

Because there is no published experience with sibutramine during breastfeeding, an alternate therapy may be preferred, especially while nursing a newborn or preterm infant. Information on the effect of sibutramine on serum prolactin is somewhat conflicting.

In a study of hypocaloric diet plus sibutramine in overweight and obese patients with polycystic ovary syndrome, no change was seen in serum prolactin levels over the 6-month study period.[1] A woman developed amenorrhea-galactorrhea syndrome shortly after starting therapy with sibutramine for weight loss. Her serum prolactin was elevated, but returned to normal within 15 days of discontinuing sibutramine. It remained in the normal range during the 180-day follow-up period.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.