Metrogel-vaginal | Metronidazole Gel while Breastfeeding

Breast milk is superior in nutrition, It provides resistance against infections and allergies, It is naturally sterile. Despite all the advantages of breastfeeding some mothers choose to pause the breastfeeding in fear of harmful effects of medicines passing in breast milk. Are you wondering about breastfeeding and using Metrogel-vaginal | Metronidazole Gel ? Know what is Metrogel-vaginal | Metronidazole Gel and how it can affect your breast milk and whether Metrogel-vaginal | Metronidazole Gel is safe for your kid or not.

What is Metrogel-vaginal | Metronidazole Gel used for?


METROGEL-VAGINAL is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis). NOTE: For purposes of this indication, a clinical diagnosis of bacterial vaginosis is usually defined by the presence of a homogeneous vaginal discharge that (a) has a pH of greater than 4.5, (b) emits a “fishy” amine odor when mixed with a 10% KOH solution, and (c) contains clue cells on microscopic examination. Gram's stain results consistent with a diagnosis of bacterial vaginosis include (a) markedly reduced or absent Lactobacillus morphology, (b) predominance of Gardnerella morphotype, and (c) absent or few white blood cells. Other pathogens commonly associated with vulvovaginitis, e.g., Trichomonas vaginalis, Chlamydia trachomatis, N. gonorrhoeae, Candida albicans, and Herpes simplex virus should be ruled out.

Metrogel-vaginal | Metronidazole Gel while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Metrogel-vaginal | Metronidazole Gel safe for breastfeeding
Metronidazole is the only one ingredient used in manufacturing of Metrogel-vaginal | Metronidazole Gel, Which makes it easier to analyze its effect in breastfeeding. As per our analysis of Metronidazole it is safe to use Metrogel-vaginal | Metronidazole Gel while lactating. We suggest you to check further details below about Metronidazole usage in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers: Specific studies of metronidazole levels in human milk following intravaginally administered metronidazole have not been performed. However, metronidazole is secreted in human milk in concentrations similar to those found in plasma following oral administration of metronidazole. Because of the potential for tumorigenicity shown for metronidazole in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Metrogel-vaginal | Metronidazole Gel Breastfeeding Analsys


Metronidazole while Breastfeeding

Safe

CAS Number: 443-48-1

Excreted into breast milk in a non-significant clinical amount. Not problems on breastfed infants of treated mothers were found. Plasma levels were low or undetectable in those infants. For a mother's dose of 400 mg three times-a-day, the intake of a breastfed infant would be less than 10% of the usual daily pediatric dose, whenever the breast-feed is done within 2-3 hours of mother's intake. Widely used for treatment of Giardia lamblia infections, even in small infants, without adverse effects reported. Metronidazole may produce a red discoloration of corporal fluids and bitter flavor of the milk with no harm effect on the child.


Metrogel-vaginal | Metronidazole Gel Breastfeeding Analsys - 2


Metronidazole while Breastfeeding

CAS Number: 443-48-1

Metrogel-vaginal | Metronidazole Gel and breastfeeding

With maternal intravenous and oral therapy, breastfed infants receive metronidazole in doses that are less than those used to treat infections in infants, although the active metabolite adds to the total infant exposure. Plasma levels of the drug and metabolite are measurable, but less than maternal plasma levels. Case reports of candidal infections and diarrhea have been reported, and a comparative trial suggested that oral and rectal colonization with might be more common in infants exposed to metronidazole. Neither topical nor vaginal metronidazole have been studied during breastfeeding. After vaginal administration, plasma levels are less than 2% of those after a 500 mg oral dose. After topical administration, blood levels are about 1% of the peak plasma levels after a 250 mg oral dose. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1] Because of the well demonstrated genotoxicity and mutagenicity in bacteria, carcinogenicity in animals, and possible mutagenicity in humans,[2][3] concern has been raised about exposure of healthy infants to metronidazole via breastmilk.[4] The relevance of these findings has been questioned and no definitive study has yet been performed in humans.[3][5] Opinions vary among experts on the advisability of using metronidazole during longer-term therapy while breastfeeding, but some sources recommend discontinuing breastfeeding for 12 to 24 hours after single-dose maternal treatment.[4][6] Other drugs are available for some conditions that metronidazole is used to treat. Topical or vaginal use of metronidazole during breastfeeding is unlikely to be of concern, although the manufacturer of one vaginal product recommends not breastfeeding during treatment and for 2 days after the last dose.


Is Metrogel-vaginal | Metronidazole Gel safe while breastfeeding

What if I already have used Metrogel-vaginal | Metronidazole Gel?

It is always a good idea to keep your healthcare provider or doctor informed about your drug usage during pregnancy and breastfeeding but if you have not informed your doctor about Metrogel-vaginal | Metronidazole Gel and have used it then do not panic as Metrogel-vaginal | Metronidazole Gel is mostly safe in breastfeeding and should not cause any harm to your baby.


I am nursing mother and my doctor has suggested me to use Metrogel-vaginal | Metronidazole Gel, is it safe?

Definitely, Metrogel-vaginal | Metronidazole Gel is safe in lactation for baby. No wonder your doctor has recommended it.


If I am using Metrogel-vaginal | Metronidazole Gel, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Metrogel-vaginal | Metronidazole Gel


Who can I talk to if I have questions about usage of Metrogel-vaginal | Metronidazole Gel in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week