Do you know that important immune protective proteins are present in breast milk? Breast milk also contains required vitamins, minerals, saturated and un saturated fats. These things are extremely important for development of healthy brain. If you are taking any medicine for short term or for the chronic reason then that passes in breast milk as well, that is why you should always check the drug with your health care provider. Here at DrLact we try to analyze drugs based on available researches and in this sheet we will present our analysis for Januvia | Sitagliptin 100 Mg.
What is Januvia | Sitagliptin 100 Mg used for?
JANUVIA is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. (1.1) Important Limitations of Use: •JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. (1.2) •JANUVIA has not been studied in patients with a history of pancreatitis. (1.2, 5.1) 1.1 Monotherapy and Combination Therapy JANUVIA® is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. [See Clinical Studies (14).] 1.2 Important Limitations of Use JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings. JANUVIA has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using JANUVIA. [See Warnings and Precautions (5.1).]
I am breastfeeding mother and I am using Januvia | Sitagliptin 100 Mg. Can it have any bad effect on my kid? Shall I search for better alternative?
Januvia | Sitagliptin 100 Mg contains only one active ingredient that is Sitagliptin. We have analyzed the usage of Sitagliptin in breastfeeding and our analysis suggest that Sitagliptin poses Low risk for infant while breastfeeding and hence Januvia | Sitagliptin 100 Mg itself shall be considered Low risk item for breastfeeding.
Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Sitagliptin is secreted in the milk of lactating rats at a milk to plasma ratio of 4:1. It is not known whether sitagliptin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when JANUVIA is administered to a nursing woman.
Januvia | Sitagliptin 100 Mg Breastfeeding Analsys
Sitagliptin while Breastfeeding Low Risk
CAS Number: 654671-77-9
It promotes pancreatic insulin secretion by inhibiting the DPP-4 enzyme that degrades the intestinal hormone GLP-1 that is activated when eating (Baetta 2011, Scheen 2011).Oral administration, once daily.Very low risk of hypoglycemia. Doses 6 times higher than normal for 10 days or 4 times higher for 28 days do not produce side effects (EMA 2016). The most common side effect is rhinopharyngitis. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (EMA 2016, Scheen 2011): large volume of distribution, moderately high molecular weight and low liposolubility, make it unlikely that it will pass through to breast milk in significant amounts. Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity. Diet, exercise, and breastfeeding improve blood sugar levels. Among the antidiabetics of this same group, Saxagliptin and Vildagliptin would be preferable due to their short half-life (less than 3 hours). See below the information of these related products:
Januvia | Sitagliptin 100 Mg Breastfeeding Analsys - 2
Sitagliptin while Breastfeeding
CAS Number: 486460-32-6
No information is available on the clinical use of sitagliptin during breastfeeding. If sitagliptin is required by the mother, it is not a reason to discontinue breastfeeding. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Saxagliptin has a shorter half-life than the other dipeptidyl-peptidase IV inhibitors and linagliptin is highly protein bound, so these might be better choices among drugs in this class for nursing mothers.
I already used Januvia | Sitagliptin 100 Mg and meanwhile I breastfed my baby should I be concerned?
Januvia | Sitagliptin 100 Mg is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Januvia | Sitagliptin 100 Mg so you should inform him based on your convenience.
I am nursing mother and my doctor has suggested me to use Januvia | Sitagliptin 100 Mg, is it safe?
Januvia | Sitagliptin 100 Mg comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.
If I am using Januvia | Sitagliptin 100 Mg, will my baby need extra monitoring?
Not much monitoring required while using Januvia | Sitagliptin 100 Mg
Who can I talk to if I have questions about usage of Januvia | Sitagliptin 100 Mg in breastfeeding?
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week