CAS Number: 79-83-4
Pantothenic acid, dexpanthenol or vitamin B5 is widely distributed in nature being very abundant in meat, vegetables, cereals, legumes, eggs, milk, fruit and vegetables (MedlinePlus 2015), therefore its deficiency is very rare. The only recognized indication for administering pantothenic acid is to treat vitamin B5 deficiency. There is no evidence that it can be used to treat any other disease or condition. (MedlinePlus 2015). Daily requirements are 2 mg in infants, 4 in children, 5 in adults, 6 in pregnant women and 7 mg in breastfeeding mothers (Ares 2015, MedlinePLus 2015). Pantothenic acid is excreted in breast milk at a concentration of 2 to 2.7 mg/L (Sakurai 2005, Song 1984) with little variation throughout breastfeeding (Ren 2015, Johnston 1981) and is directly proportional to maternal ingestion (Song 1984, Johnston 1981). The concentration is higher in milk of mothers of premature babies than in full-term infants (Ford 1983). With a varied and balanced diet, supplements of this vitamin are not needed during breastfeeding, it is enough to adequately select the food in one’s diet (Song 1985). Topical use, most commonly used as panthenol or provitamin B5, regardless of its questionable efficacy, is compatible with breastfeeding.
CAS Number: 50-21-5
A natural product found in milk that may increase their concentration after exercise which is not harmful to the infant. At latest update published were not found data on excretion in breast milk.Because the small dose used and poor absorption to the plasma of most topical dermatological or vaginal preparations, make it unlikely the pass of a significant amount into breast milk. Do not apply on the nipple or areola.
CAS Number: 303-98-0
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CAS Number: 73-22-3
Essential amino acid that is not produced by the body and must be taken from the diet.It is naturally found in many proteins of animal and plant origin (eggs, milk, cheese, soy, marine fish, nuts).It is a precursor of serotonin (George 1989, Yurcheshen 2015) through its metabolite 5-HTP or Oxitriptan (see card) and is credited with antioxidant properties (Tsopmo 2009).There is no conclusive scientific evidence that tryptophan supplements are effective on depression, insomnia, attention deficit, other diseases or improvement of physical performance (Yurcheshen 2015).It has been associated to a serious outbreak of Eosinophilia-Myalgia Syndrome with more than 1,500 cases and 37 deaths occurring in the 1990s, possibly caused by contaminated or poorly prepared batches of tryptophan (Falk 2011, Allen 2011, Sachs 2013, Yurcheshen 2015, Mediine Plus 2015). The FDA has launched a precautionary measure by withdrawing it from the market for years. At high doses it may cause side effects that are harmful to health (Fernstrom 2012). Tryptophan is a natural component of breast milk, with higher concentration in colostrum than in mature milk (Zarando 1989, Kamimura 1991) which is believed to have a circadian rhythm that regulates the sleep pattern and behavior of the infant ( Heine 1995, Cubero 2005).By taking tryptophan or alpha-lactalbumin (a high tryptophan-containing protein) tryptophan levels in breast milk is not increased (Dowlati 2015), but plasma prolactin concentration doest it (Chaney 1982, Cowen 1985) . With a comprehensive diet, tryptophan supplements are not needed at all, as their effectiveness has not been proven yet in any disease or disorder.Whenever used, a moderate consumption is recommended, making sure a reliable source since poisoning has been reported in the past.
CAS Number: 73-31-4
Hormone secreted by Pineal gland which exerts its function by regulating the Circadian pattern of sleeping. It is naturally found in the mother's milk. The level of Melatonin in the plasma and breast milk increases by night. It is believed that helps to organize the sleep - awake cycle in breastfed newborns and infants. It has antioxidant and anti-inflammatory properties, and, it is found in many foods, either vegetable or animal in origin (meat, fish), eggs, wine and beer. On latest update, no relevant published data related to breastfeeding were found, however, known side-effects are mild and few. It is being used for co-treatment of several conditions in newborn infants and prematures, with good tolerance in spite of higher doses than those excreted in the breast milk.
Used in the treatment of promyelocitic leukemia in adults.
The seeds of this leguminous plant are used. Content: carbohydrates, proteins, saponins, vitamins, minerals . Assigned properties: appetite stimulant, lowering of lipemia and glycemic (Gong 2016).Indications according to Commission E of the German Ministry of Health: Anorexia, Atopic Dermatitis. Widely used as a galactogogue in many cultures around the world (Ayers 2000, Winterfeld 2012, Sim 2013, The Royal Women's .. 2013, Bazzano 2016). Case-control studies looking for evidence on the increment of milk production associated to the use of fenugreek are few (Turkyılmaz 2011, Ghasemi 2015), along with a variety of methodological deficiencies. Other studies have failed to find such an effect with the use of fenugreek (Damanik 2006). Studies with an appropriate design are needed to provide high quality evidence to make clinical recommendations on its use (Forinash 2012, Zapantis 2012, Committee LM AEP 2012, Mortel 2013, Bazzano 2016) A higher antioxidant effect in the breastmilk of women who have consumed mixed infusions containing this or other herbs has not been shown (Kavurt 2013). Given the wide spread use and lack of toxicity of this herb, a moderate consumption would be compatible with breastfeeding, yet high doses may produce hypoglycemia (EMA 2011, Gong 2016) and, because of the odor appearing in the urine of the infant, a lab test may be required to make a differential diagnosis with maple syrup disease of the newborn (Sewell 1999, Korman 2001). Avoid the use of a galactogogue without a sanitary control. Best galactagogue results are achieved through on-demand breastfeeding along with an adequate technique in a mother who is able to maintain self-confidence (ABM 2011, Mannion 2012). Precautions when taking plant preparations: 1. Ensure that they are from a reliable source: poisoning has occurred due to confusing one plant with another with toxic properties, as well as poisoning from heavy metals extracted from the ground and food poisoning due to contamination with bacteria or fungi. 2. Do not take in large amounts; follow recommendations from professional experts in phytotherapy. "Natural" products are not always good in any quantity: plants contain active substances from which much of our traditional pharmacopoeia has been obtained and can result in poisoning or act as endocrine disruptors if taken in excessive amounts or time periods.
CAS Number: 84650-00-0
Infant intake after usual daily consumption of the mother is lower than usual recommended dose for neonatal apnea treatment. Elimination-time period may last from few hours in adults, to 3-4 days in the newborn infant. At higher dose (more than 300 mg per day) caffeine may induce irritability, tremor and insomnia in the infant. However, some infants may develop irritability at a lower dose; in those cases the mother should decide appropriate coffee intake. Some studies have failed to show harmful effect among infants whose mothers were strong coffee consumers even during pregnancy. Daily intake as high as 1 liter or more has been associated to anemia and iron deficiency in mothers and breastfed infants. Also, has been related to the Raynaud's phenomenon in the nipple of nursing women. Mean Caffeine content: 1 coffee cup: 100 mg, 1 black tea cup: 80 mg, 1 green tea cup: 50 mg, 1 liter of cola & soda and energizers beverages 100 to 340 mg. See also Caffeine as medication. The American Academy of Pediatrics rates it compatible with breastfeeding.
CAS Number: 8057-62-3
At latest update, relevant information on excretion into breast milk was not found. Aerial summits of this climbing plant are used. Constituents are: flavonoids, pyranics, heterosides, alkaloids. Attributed effects with only weak scientific evidence on effectiveness are: sedative, hypnotic, anti-spasmodic. Because of paucity of data on toxicity, recommendations done are to use it at low doses for short term periods. The European Medicines Agency does not authorize its use for children younger than 12 years old , pregnancy and breastfeeding. When used while breastfeeding, it is recommended to use it at low dose for a short-term period. Following-up the infant for sedation is recommended.
A polymer made out of silicon-oxygen-methyl combination with a high molecular weight, water repellent and low superficial tension. It is used in many ways (dimethicone, simethicone, -see specific items)orally to treat infant colic and flatulence; as pediculicide, in cosmetic creams and lotions and skin protectants as to prevent ulcers and scars; arthroplasties, retinal detachments and reconstruction or cosmetic surgery as injections and implants. Silicone is widely distributed in our environment with several cosmetic and medicinal uses. No evidence of toxicity on human tissues has been shown. A 1994 report on immunological side effects in infants breastfed by mothers with silicone implants, was denied categorically by means of meta-analysis and other work. The absorption by oral or dermal route is negligible. Both a high molecular weight and polymer molecular structure make it practically impossible excretion in the milk and hence a significant amount of intestinal absorption by the infant. Those circumstances make silicone implants safe for lactation even if broken or manufacturing fault (Poly Implant Prothèse, PIP). After extensive analysis of such silicone prosthesis, where lack of health risk was demonstrated, it can be concluded that many of the initial recommendations published lacked scientific validity, including that carriers of such prosthesis should not breastfeed. Silicon levels in blood and milk of women with implants (55 ng / ml) are similar to those of women without implants (51 ng / ml), 13 times lower than that found in cow's milk (709 ng / ml) and 80 times lower than in commercial infant formulas (4403 ng / ml). American Academy of Pediatrics: Product usually compatible with breastfeeding. To view other possible effects on breastfeeding of breast implant unrelated to silicone, see the term 'Augmentation Mammoplasty'. See below the information of these related products:
Zinc (Zn) is an essential element for nutrition. It is present in many foods.Recommended daily allowance of Zn is 8 to 15 mg. (Moran Hall 2010). Millions of people worldwide are Zn-deficient.It is used as a treatment for Wilson's disease and Acrodermatitis Enteropathica. Zn is involved in the regulation process of lactation (Lee 2016).Pasteurization of the milk does not affect the concentration of Zn and other trace elements (Mohd Taufek-2016). The average concentration of Zn in breastmilk is 4 to 16 mg / L (Picciano 1976, Hannan 2005, Dórea 2012) which is independent of plasma levels and maternal daily intake (Krebs 1995, Chierici 1999, Hannan 2009).Intestinal absorption of zinc is almost doubled during pregnancy and lactation (Fung 1997).Zinc levels in the infant are dependent on Zinc levels in the breast milk (Dumrongwongsiri 2015)With a varied and balanced diet, an extra intake of minerals is not needed. Excessive intake of Zinc may cause gastrointestinal problems and Pancytopenia (Irving 2003).
CAS Number: 1339-63-5
Coenzyme Q10 (ubiquinone) is a normal part of the diet, and is also endogenously synthesized. It is a normal component of human milk, but milk levels are slightly low in the breastmilk of mothers with preterm infants. Coenzyme Q10 has no specific lactation-related uses and no data exist on the safety and efficacy of supplementation in nursing mothers or infants. Coenzyme Q10 supplements are usually well tolerated with only infrequent, minor side effects. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.
CAS Number: 73-31-4
Melatonin is the hormone produced by the pineal gland that plays a role in regulating sleep and circadian rhythm as well as a possible role in gut-brain signaling. It is a normal component of breastmilk, with concentrations higher during nighttime than daytime. Some authors suggest that mothers should nurse in the dark at night in order to avoid reductions in the melatonin content of breastmilk, which could disturb infant sleep patterns. Differentiating milk pumped during the day from milk pumped during darkness has also been suggested for women pumping milk for their infants. Some studies have attributed longer sleep time in breastfed infant than in formula-fed infants to melatonin in breastmilk. Another study found higher colostrum melatonin levels at night which appeared to increase the phagocytic activity of colostral cells against bacteria. Exogenous administration of melatonin has no specific use during breastfeeding and no data exist on the safety of maternal use of melatonin during breastfeeding. However, doses higher than those expected in breastmilk after maternal supplementation have been used safely in infants. It is unlikely that short-term use of usual doses of melatonin in the evening by a nursing mother would adversely affect her breastfed infant, although some authors recommend against its use in breastfeeding because of the lack of data and a relatively long half-life in preterm neonates. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.
CAS Number: 1327-53-3
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence; the manufacturer recommends an abstinence period of 1 week after the last dose. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk. Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.
Due to high dilution of ingredients in homeopathic medicines they do not create much problem for baby. Sleep Tight is a homeopathic medicine and if your baby does not have any abnormal symptoms then there is nothing to worry about. Be careful with too much usage of ethanol based homeopathic medicines during breastfeeding.
Homeopathic medicines are usually safe in breastfeeding and if Sleep Tight has been recommended by doctor then there should be no concern about its usage in breastfeeding.
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week