Viatrexx-facial while Breastfeeding

What is Viatrexx-facial used for?

Is Viatrexx-facial usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Fumaric acid while Breastfeeding

CAS Number: 110-17-8

Anti-inflammatory and immunomodulator used in the treatment of psoriasis and in relapsing forms of multiple sclerosis. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (large volume of distribution and short half-life) make it unlikely that milk would pass through in significant quantities (Almas 2016).Possible side effects are rare and generally not serious, with no immunosuppressive effects or higher frequency of infections (EMA 2017, AEMPS 2015). Until there is more published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in case of prematurity (Brown 2017, Yiu 2015, Bove 2014, Cree 2013).

Ginkgo while Breastfeeding

CAS Number: 90045-36-6

Leaves of tree are used.It contains flavonoids, tannins, diterpenes, steroids..Unproved effects: venous tonic, capillary protector, vasodilator (neuron-protector) and platelet anti-aggregationIndications after Commission E of German Ministry of Health: brain vascular insufficiency, intermittent claudication, dizziness, tinnitus. Fluids or solutions with alcoholic content are to be avoided.

Hyaluronidase while Breastfeeding

CAS Number: 9001-54-1

Enzyme obtained from testes of mammals that acts by depolymerization of mucopolysaccharides like hyaluronic acid. It is used to facilitate the diffusion of local anesthetics.

Potassium aspartate while Breastfeeding

CAS Number: 7447-40-7

Human milk has a potassium concentration of 13 meq/L, almost a half of rehydration solution content and a quarter of maximal IV recommended dose. Potassium supplementation does not alter milk concentration without increasing mother’s serum concentration, which is strictly limited from 3,5 to 5,5 meq/L.

Thiamine while Breastfeeding

CAS Number: 59-43-8

Thiamine or Vitamin B1 is a water soluble vitamin. In addition to Thiamine, other chemical compounds with similar activity: Acetiamine, Benfotiamine, Bisbentiamine, Bisbutiamina, Cetotiamina, Cicotiamina, Cocarboxylase, Fursultiamine, Monofosfotiamina, Octotiamine, Pyrophosphotiamine, Prosultiamine and Sulbutiamine.It is essential for the metabolism of carbohydrate nutrients. Its deficiency causes severe neuromuscular and cardiac symptoms known as Beriberi and Wernicke-Korsakoff disease. Thiamine deficiency is common among disadvantaged populations in Southeast Asia (predominantly consumers of refined rice), other malnourished people (refugees, low socioeconomic status ...) and chronic alcohol consumption. Beriberi of childhood, both infants and children, may arise from breastfeeding by Thiamine deficient mothers. Reportedly, several severe cases have occured after feeding the babies with artificial formulas that were not supplemented with vitamin B1. Daily allowance is higher during pregnancy and lactation (1.5 mg / day) which is readily obtained through a varied diet with adequate content of whole grains, legumes, nuts, eggs and lean meat.Thiamine is excreted in breast milk and gradually increases with time, being lower in colostrum (28 ng / mL) and transitional milk than in mature milk (180 ng / mL). The concentration is lower in milk from mothers of preterm (90 ng / mL). Taking vitamin supplementation is not required if diet and nutritional status are adequate. Supplementation does not increase levels in milk of well-nourished women, but of those with a low nutritional status. The supplementation of group B vitamins and C and E vitamins to HIV positive mothers improves the weight growth of their breasted babies.There is no evidence of their effectiveness in improving athletic performance, lack of appetite, sores, stress, fatigue or aging.Toxicity linked to excessive consumption of thiamine is not known. WHO List of Essential Medicines 2002: compatible with breastfeeding.American Academy of Pediatrics: usually compatible with breastfeeding

Riboflavin while Breastfeeding

CAS Number: 83-88-5

A balanced and comprehensive diet make it vitamin supplementation useless.

Pantothenic acid while Breastfeeding

CAS Number: 79-83-4

Pantothenic acid, dexpanthenol or vitamin B5 is widely distributed in nature being very abundant in meat, vegetables, cereals, legumes, eggs, milk, fruit and vegetables (MedlinePlus 2015), therefore its deficiency is very rare. The only recognized indication for administering pantothenic acid is to treat vitamin B5 deficiency. There is no evidence that it can be used to treat any other disease or condition. (MedlinePlus 2015). Daily requirements are 2 mg in infants, 4 in children, 5 in adults, 6 in pregnant women and 7 mg in breastfeeding mothers (Ares 2015, MedlinePLus 2015). Pantothenic acid is excreted in breast milk at a concentration of 2 to 2.7 mg/L (Sakurai 2005, Song 1984) with little variation throughout breastfeeding (Ren 2015, Johnston 1981) and is directly proportional to maternal ingestion (Song 1984, Johnston 1981). The concentration is higher in milk of mothers of premature babies than in full-term infants (Ford 1983). With a varied and balanced diet, supplements of this vitamin are not needed during breastfeeding, it is enough to adequately select the food in one’s diet (Song 1985). Topical use, most commonly used as panthenol or provitamin B5, regardless of its questionable efficacy, is compatible with breastfeeding.

Pyridoxine while Breastfeeding

CAS Number: 65-23-6

Concentration of vitamin B6 in the breast milk is directly related to the amount present in diet with the possibility of a high increment by an excessive consumption through the diet. Daily allowance of vitamin B6 ranges from 2 to 3 mg. A balanced and varied diet is enough without a need for extra supplementation with this vitamin. Vitamin B6 deficiency is extremely rare since it is widely distributed in many foods. In those cases where supplementation is required, it is recommended not to exceed 40 mg a-day. There are controversial data on the capacity of a high dose of Pyridoxine to inhibit the secretion of Prolactin and suppress the milk production. The American Academy of Pediatrics rates it as usually compatible with breastfeeding.

Cyanocobalamin while Breastfeeding

CAS Number: 68-19-9

Vitamin B12 exists naturally in milk at a concentration of 1 nanogram / mL (range: 0.3 to 3 ng / mL). Maternal supplementation with cyanocobalamin barely increases milk levels in well-nourished women (Sandberg 1981), but it does improve the levels in women of low socioeconomic status (Sneed 1981). The concentration in colostrum is up to 28 times higher than that of mature milk.The daily requirements for Vitamin B12 are 2.4 micrograms and increase to 2.8 micrograms daily during breastfeeding. Foods rich in vitamin B12 are meat, offal, eggs, dairy products, salmon, sardines, clams and fortified cereals. With a varied and balanced diet no vitamin supplements are needed, but B12 deficiency has been observed in the plasma and milk of women with strict vegetarian diets (vegans), malabsorptive diseases (eg, Crohn's disease, celiac disease), bariatric surgery, poor nutritional status, pernicious anemia, low socio-economic status and in cases of natural disasters or wars. There are numerous publications showing that infants of these mothers are at high risk of disease due to vitamin B12 deficiency, which can lead to anemia, stunting and psychomotor retardation. "Flash pasteurization" applied to breast milk of mothers who are HIV+ does not decrease vitamin B12 concentration. American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

Folic acid while Breastfeeding

CAS Number: 59-30-3

Soluble B group vitamin that is very abundant in green vegetables, legumes and fruits (citric fruits). It is actively excreted in breast milk with priority over maternal folate in such extent that may even cause maternal deficit. Exclusive breastfeeding meets the daily allowances of infant folic acid.The concentration is higher in mature milk (85 micrograms / L) than in colostrum and premature breast milk.Administration to nursing mothers increases slightly the usual concentration of folate in breast milk. Folic acid needs are increased during pregnancy and lactation (500-600 micrograms / day) and in case of taking anticonvulsant medication. No harmful effects have been observed by taking folic acid during lactation. Excess of folic acid is eliminated by the kidneys every day. No supplements are needed if diet and nutritional status are adequate. The American Academy of Pediatrics rates it as a mediation usually compatible with breastfeeding.WHO List of Essential Medicines 2002: compatible with breastfeeding.

Quinhydrone while Breastfeeding

CAS Number: 123-31-9

Benzene derivative which is topically used with creams and solutions (2-4%) as a bleaching agent for several skin disorders associated to hyper-pigmentation. In industry it is used as photographic developer. TLV or threshold limit value which means maximum exposure limit for workers is 2 mg / m3 (Flickinger 1976). At latest update relevant published data were not found on excretion into breast milk. It is well absorbed through the skin, both when used as a therapeutic agent (Bucks 1998, Wester 1998, Westerhof 2005, Andersen 2010, Bozzo 2011) or industrial use (Barber 1995, McGregor 2007), however, a significant excretion into breastmilk is not likely for their lack of fat solubility. There is controversy and doubt about a possible mutagenic and carcinogenic effect (Kooyers 2004, FDA 2006, Levitt 2007, Andersen 2010), so it does not seem wise a chronic or continued use while breastfeeding. Do not apply it on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed.Do not apply it over large areas or on long-term treatments to avoid an excessive systemic absorption.

Silicon dioxide while Breastfeeding

A polymer made out of silicon-oxygen-methyl combination with a high molecular weight, water repellent and low superficial tension. It is used in many ways (dimethicone, simethicone, -see specific items)orally to treat infant colic and flatulence; as pediculicide, in cosmetic creams and lotions and skin protectants as to prevent ulcers and scars; arthroplasties, retinal detachments and reconstruction or cosmetic surgery as injections and implants. Silicone is widely distributed in our environment with several cosmetic and medicinal uses. No evidence of toxicity on human tissues has been shown. A 1994 report on immunological side effects in infants breastfed by mothers with silicone implants, was denied categorically by means of meta-analysis and other work. The absorption by oral or dermal route is negligible. Both a high molecular weight and polymer molecular structure make it practically impossible excretion in the milk and hence a significant amount of intestinal absorption by the infant. Those circumstances make silicone implants safe for lactation even if broken or manufacturing fault (Poly Implant Prothèse, PIP). After extensive analysis of such silicone prosthesis, where lack of health risk was demonstrated, it can be concluded that many of the initial recommendations published lacked scientific validity, including that carriers of such prosthesis should not breastfeed. Silicon levels in blood and milk of women with implants (55 ng / ml) are similar to those of women without implants (51 ng / ml), 13 times lower than that found in cow's milk (709 ng / ml) and 80 times lower than in commercial infant formulas (4403 ng / ml). American Academy of Pediatrics: Product usually compatible with breastfeeding. To view other possible effects on breastfeeding of breast implant unrelated to silicone, see the term 'Augmentation Mammoplasty'. See below the information of these related products:

Ginkgo while Breastfeeding

CAS Number: 90045-36-6

Ginkgo (Ginkgo biloba) leaf contains flavonoids (e.g., quercetin, kaempferol, isorhamnetine) and several terpene trilactones (e.g., ginkgolides, bilobalide) as well as numerous minor components. Standardization is based on ginkgo flavone glycoside and terpenoid content. Raw ginkgo seeds contain potentially toxic cyanogenic glycosides and should not be used; roasted seeds do not carry this risk. Ginkgo has no specific uses during breastfeeding, but is commonly used as an antioxidant, a vasodilator to increase cerebral and peripheral perfusion, and to improve memory. No data exist on the safety and efficacy of ginkgo in nursing mothers or infants. In general, it is well tolerated, but occasionally minor symptoms (e.g., headache, nausea, gastrointestinal complaints, allergic skin rashes) occur in those taking the drug. Ginkgo has caused some cases of bleeding in healthy volunteers caused by its antiplatelet activity. Because there is no published experience with ginkgo during breastfeeding, an alternate therapy may be preferred, especially while nursing a newborn or preterm infant.[1] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.

Cyanocobalamin while Breastfeeding

CAS Number: 68-19-9

Vitamin B12 is a normal component of human milk.[1] The recommended daily intake in lactating women is 2.8 mcg and for infants aged 6 months or less is 0.4 mcg.[2] Lactating mothers may need to supplement their diet to achieve the recommended daily intake or to correct a known deficiency. Low doses of vitamin B12 found in B complex or prenatal vitamins increase milk levels only slightly. Higher daily doses of 50 to 100 mcg or more are needed in cases of maternal deficiency. The breastfed infant is not exposed to excessive vitamin B12 in such cases, and their vitamin B12 status should improve if it was previously inadequate. Poor health outcomes in infants with vitamin B12 deficiency include anemia, abnormal skin and hair development, convulsions, failure to thrive, and mental developmental delay. One well-recognized at risk group are exclusively breastfed infants of mothers with B12 deficiency due to minimal or no dietary intake of animal products.[3][4][5][6][7][8][9] Infant vitamin B12 status can be improved through maternal B12 supplementation during pregnancy and lactation.[10][11][12][13] Deficient mothers who miss the opportunity to supplement during pregnancy should still be encouraged to supplement during early lactation since infant vitamin B12 status correlates with milk vitamin B12 levels in breastfed infants up to 6 months of age.[14][15][16][17] Although there are cases reported of exclusively breastfed infants with vitamin B12 deficiency having biochemical and clinical improvement through adequate maternal supplementation alone,[3] direct supplementation of the infant is recommended when such treatments are available.[18][19][8] Flash heat pasteurization of breastmilk does not reduce milk vitamin B12 concentration.[20]

Quinhydrone while Breastfeeding

CAS Number: 123-31-9

Topical hydroquinone has not been studied during breastfeeding. Hydroquinone is not contraindicated during breastfeeding and if hydroquinone is required by the mother, it is not a reason to discontinue breastfeeding. However, some experts feel that long-term use of hydroquinone is difficult to justify in a nursing mother.[1] If hydroquinone is used, ensure that the infant's skin does not come into direct contact with the areas of maternal skin that have been treated and the infant does not ingest the product from the mother's skin.

I already used Viatrexx-facial and meanwhile I breastfed my baby should I be concerned?

I am nursing mother and my doctor has suggested me to use Viatrexx-facial, is it safe?

If I am using Viatrexx-facial, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Viatrexx-facial in breastfeeding?