Metronidazole Vaginal | Metronidazole Gel while Breastfeeding

What is Metronidazole Vaginal | Metronidazole Gel used for?

What are the risk associated with Metronidazole Vaginal | Metronidazole Gel usage while breastfeeding? What precautions shall I take while using it in breastfeeding?

Metronidazole while Breastfeeding

CAS Number: 443-48-1

Excreted into breast milk in a non-significant clinical amount. Not problems on breastfed infants of treated mothers were found. Plasma levels were low or undetectable in those infants. For a mother's dose of 400 mg three times-a-day, the intake of a breastfed infant would be less than 10% of the usual daily pediatric dose, whenever the breast-feed is done within 2-3 hours of mother's intake. Widely used for treatment of Giardia lamblia infections, even in small infants, without adverse effects reported. Metronidazole may produce a red discoloration of corporal fluids and bitter flavor of the milk with no harm effect on the child.

Metronidazole while Breastfeeding

CAS Number: 443-48-1

With maternal intravenous and oral therapy, breastfed infants receive metronidazole in doses that are less than those used to treat infections in infants, although the active metabolite adds to the total infant exposure. Plasma levels of the drug and metabolite are measurable, but less than maternal plasma levels. Case reports of candidal infections and diarrhea have been reported, and a comparative trial suggested that oral and rectal colonization with might be more common in infants exposed to metronidazole. Neither topical nor vaginal metronidazole have been studied during breastfeeding. After vaginal administration, plasma levels are less than 2% of those after a 500 mg oral dose. After topical administration, blood levels are about 1% of the peak plasma levels after a 250 mg oral dose. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1] Because of the well demonstrated genotoxicity and mutagenicity in bacteria, carcinogenicity in animals, and possible mutagenicity in humans,[2][3] concern has been raised about exposure of healthy infants to metronidazole via breastmilk.[4] The relevance of these findings has been questioned and no definitive study has yet been performed in humans.[3][5] Opinions vary among experts on the advisability of using metronidazole during longer-term therapy while breastfeeding, but some sources recommend discontinuing breastfeeding for 12 to 24 hours after single-dose maternal treatment.[4][6] Other drugs are available for some conditions that metronidazole is used to treat. Topical or vaginal use of metronidazole during breastfeeding is unlikely to be of concern, although the manufacturer of one vaginal product recommends not breastfeeding during treatment and for 2 days after the last dose.

What should I do if already breastfed my kid after using Metronidazole Vaginal | Metronidazole Gel?

My health care provider has asked me to use Metronidazole Vaginal | Metronidazole Gel, what to do?

If I am using Metronidazole Vaginal | Metronidazole Gel, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Metronidazole Vaginal | Metronidazole Gel in breastfeeding?